Dr. Calum MacRae is a cardiologist, geneticist, and developmental biologist who trained in Edinburgh, London, and Boston. He is vice chair for scientific innovation, chief executive of One Brave Idea, chief of cardiovascular medicine at Brigham and Women’s Hospital, and associate professor of medicine at Harvard Medical School. He is also an associate member at the Broad Institute and a principal faculty member at the Harvard Stem Cell Institute. His research is focused on understanding the fundamental mechanisms of disease, using human studies and complementary efforts, combining systems-level modeling with empiric high-throughput biology in the zebrafish. His lab uses automated screens in fish to define the genetic architecture of disease and to explore gene-drug (or environment) interactions through the interrogation of large-scale chemical libraries. His clinical interests include general cardiology, genomic medicine, innovation in phenotyping, and the redesign of clinical care.