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Portfolio Companies

We support companies that are working to solve important healthcare needs via cutting-edge breakthroughs in medicine and science. Since inception in 2008, we have invested in 55 companies, realized 16 successful exits, and produced top venture returns.

Active portfolio companies

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    Abcuro

    Abcuro is developing first-in-class immunotherapies for the treatment of autoimmune diseases and cancer through precise modulation of highly cytotoxic T and NK cells.

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    Affinia Therapeutics

    Affinia is developing next-generation AAV gene therapies for rare and non-rare diseases. 

  • abstract image of human eye
    Claris Bio

    Claris is a pre-clinical stage company focused on novel therapeutics for front of the eye diseases. 

  • illustration showing neurodegenerative diseases of the eye
    FireCyte Therapeutics

    FireCyte is developing novel treatment strategies for progressive neurodegenerative diseases of the eye.

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    Garuda Therapeutics

    Garuda is pioneering off-the shelf, long-term hematopoietic stem cell (LT-HSC)-based cellular therapies. 

  • child sitting against a wall with head in his legs
    InStride Health

    Co-founded by clinicians from McLean Hospital, InStride offers technology-enhanced mental health treatment for adolescents.

  • hand holding 2 pills
    Lyndra Therapeutics

    Lyndra is developing orally administered, ultra-long-acting, sustained-release drugs. The pipeline includes therapies for Alzheimer’s disease, HIV, and a once-monthly option for oral contraception.

  • scientific image showing fibrosis treatment
    Mediar Therapeutics

    Mediar is developing antibody-based therapeutics to halt fibrosis in a variety of organ systems, including lung, liver, kidney, and skin.

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    Nocion Therapeutics

    Nocion is developing novel small molecule charged sodium channel blockers, “nocions,” that selectively affect actively firing nociceptors to treat neuroinflammatory indications. 

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    Photys

    Photys is developing a new class of bifunctional drugs for phosphorylation of kinases to treat cancer.

  • image of the retina
    Pykus

    Pykus is developing a novel intraocular polymer to replace the vitreous humor following retinal surgery. 

  • pills, needle and drug containter on table with ALS in text
    QurAlis

    QurAlis is developing precision medicines for amyotrophic lateral sclerosis (ALS) and other neurologic diseases. 

  • older woman in hospital gown talking to provider
    Rippl Care

    Rippl is pioneering a new care model to expand access to mental health care for seniors, their families, and caregivers.

  • abstract image of a neuron
    ROME Therapeutics

    Rome is unlocking the hidden genome by targeting the RNA "repeatome" to treat autoimmune disease and cancer.

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    Scorpion Therapeutics

    Scorpion is a next-generation precision oncology company.

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    SeQure Dx

    SeQure Dx applies best-in-class technology to identify and manage the risks of off-target gene-editing agents.

  • abstract image of dna strand
    SwanBio Therapeutics

    SwanBio is advancing AAV-based gene therapies for the treatment of neurological diseases, including adrenomyeloneuropathy.

  • illustration of cellular connectome
    Violet Therapeutics

    Violet is leveraging first-in-class platforms to identify, map and mine the cellular connectome at scale.

  • kidney medical illustration
    Walden BioSciences

    Walden BioSciences is transforming the treatment of kidney disease by restoring or preserving podocyte function. 

  • zoomed in view of cells
    Ziel Bio

    ZielBio is developing targeted therapies against novel targets for cancer. 

Exited portfolio companies

Since inception, Mass General Brigham Ventures has realized 16 exits, including seven initial public offerings and nine trade sales. These portfolio companies are spearheading novel approaches to diagnose, prevent and treat a wide range of medical conditions.

Acquisitions

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    Adheron Therapeutics


    Acquired by Roche (ADR: RHHBY)
    Oct. 2015
    Monoclonal antibody (mAb) therapy for inflammatory diseases including rheumatoid arthritis.

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    Amolyt Pharma


    Acquired by AstraZeneca (NASDAQ: AZN)
    Mar. 2024
    Therapeutic peptides for rare endocrine and metabolic diseases.

  • woman in operating room about have oxygen mask placed on her

    Annovation BioPharma


    Acquired by The Medicines Company (NASDAQ: MDCO)
    Jan. 2015
    Novel precision anesthetics.

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    CoStim Pharmaceuticals


    Acquired by Novartis (NYSE: NVS)
    Feb. 2014
    Next-generation immuno-oncology drugs based on T-cell costimulatory targets.

  • clinician holding slide with brain scans

    LifeImage


    Acquired by Intelerad Medical Systems
    Sep. 2022
    Digital diagnostic image sharing platform.

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    Lysosomal Therapeutics


    Acquired by Bial Biotech
    Oct. 2020
    Novel personalized medicine platform to treat neurodegenerative diseases, targeting the mutant GBA1 gene.

  • doctor using tablet to view patient information

    QPID Health


    Acquired by eviCore Healthcare
    Feb. 2016
    EHR analytics software – extracting insight from information.

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    Syntimmune


    Acquired by Alexion (NASDAQ:ALXN)
    Nov. 2018
    Advances the fight against autoimmune disease.

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    Tilos Therapeutics


    Acquired by Merck (NYSE: MRK)
    June 2019
    Anti-LAP antibodies: transforming the tumor microenvironment to treat cancer.

IPOs

  • physician examining child's ear
    Akouos

    IPO June 2020 (NASDAQ: AKUS); acquired by Lilly (NYSE: LLY) Dec. 2022
    Precision genetic medicine company focused on inner ear disorders, including sensorineural hearing loss.

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    Denali Therapeutics

    IPO Dec. 2017 (NASDAQ: DNLI)
    Defeating neurodegenerative diseases.

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    Editas Medicine

    IPO Feb. 2016 (NASDAQ: EDIT)
    Unlocking the power and potential of CRISPR genome editing technology.

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    Keros Therapeutics

    IPO April 2020 (NASDAQ: KROS)
    Novel treatments for patients suffering from hematologic and musculoskeletal disorders.

  • researcher piping a sample in lab
    Magenta

    IPO June 2018 (NASDAQ: MGTA)
    Revolutionizing stem cell transplant as the new treatment paradigm for immunologic and blood-based diseases.

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    Spero Therapeutics

    IPO Nov. 2017 (NASDAQ: SPRO)
    Anti-infectives targeting Gram-negative bacteria.

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    Translate Bio

    IPO June 2018 (NASDAQ:TBIO), acquired by Sanofi (NASDAQ: SNY) Sep. 2021
    Developing messenger RNA (mRNA) therapies. 

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    Verve Therapeutics

    IPO June 2021 (NASDAQ:VERV)
    Pioneering single-course gene editing medicines to treat cardiovascular disease.