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End-Stage Heart Failure

Advanced heart failure limits activity and makes daily life difficult. Learn about congestive heart failure stages and the symptoms of end-stage heart failure. 


Heart failure describes the heart getting progressively weaker over time. Doctors divide heart failure into stages that represent the condition's progression and how it affects your daily life and activities. The most severe stage is known as end-stage heart failure or advanced heart failure. Fortunately, several treatments are available that can help stabilize or even reverse the condition at this stage, offering hope and potential for a better quality of life.
 

What is end-stage heart failure?

Despite the name, heart failure doesn't mean the heart has completely stopped functioning, which would be cardiac arrest. Instead, heart failure refers to the heart getting weaker, either because of a chronic illness that strains the heart or because of damage to the heart from an acute problem like a heart attack. The severity of heart failure gets worse over time.

Doctors use stages to describe the progression of heart failure and its effects. Advanced heart failure, also called Stage D or end-stage heart failure, is the fourth and final stage and is the most severe stage of heart failure. However, there are several treatments available that can help stabilize or even reverse the condition at this stage.
 

Heart Failure: Research and Innovative Treatments

What is heart failure? What treatments can improve your quality of life? How do we test for heart failure? Mandeep Mehra, MD, cardiologist, explains the innovative treatments for advanced heart failure that Mass General Brigham has pioneered and that may reverse or prevent this disease.

Stages of heart failure

Heart failure falls into one of four stages, depending on how advanced it is:

  • Stage A (at risk): In the first stage, you are at risk of heart failure but don't yet have symptoms or heart disease.
  • Stage B (pre-heart failure): In the second stage, you've never had symptoms of heart failure, but you do have structural heart disease, increased pressure in the heart, or other risk factors.
  • Stage C (symptomatic heart failure): In the third stage, you have symptoms of heart failure or have had symptoms in the past.
  • Stage D (advanced heart failure): In end-stage heart failure, you have severe symptoms of heart failure that interfere with daily life. You may have gone to the hospital repeatedly for heart failure symptoms.

Classes of end-stage heart failure

In addition to the stage system, doctors use a system called "classes" to further describe the last two stages (symptomatic and advanced heart failure). The classes describe the severity of your symptoms:

  • Class I: Your symptoms are mild and don't meaningfully interfere with or limit your physical activity.
  • Class II: You have some limits on physical activity. You're comfortable when resting but experience symptoms during ordinary physical activity.
  • Class III: You're comfortable at rest, but most physical activity provokes symptoms.
  • Class IV: You have symptoms of heart failure even when resting.

End-stage heart failure symptoms

Heart failure occurs when the heart becomes weaker, and end-stage heart failure means the heart is too weak to pump blood through the body effectively. When that happens, you experience symptoms related to the poor circulation of blood:

  • Shortness of breath or difficulty breathing
  • Edema (fluid buildup and swelling) in the legs, feet and torso
  • Irregular heartbeat
  • Fainting spells
  • Heart palpitations
  • Fatigue (feeling tired or weak)
  • Nausea and loss of appetite
  • Unexpected weight loss or gain
  • Coughing
  • Difficulty thinking clearly

In addition to the physical symptoms that end-stage heart failure provokes, it's common for patients with advanced heart failure to suffer psychological symptoms such as depression or anxiety about the future. Sleep problems are also common in patients with advanced heart failure.

Causes of end-stage heart failure

End-stage heart failure is the result of progressive heart failure and has many causes. It typically results from other conditions or injuries that damage the heart, such as:

Risk factors for end-stage heart failure

The risk factors for heart failure are generally the same as the causes. If you have a condition that damages the heart—especially coronary artery disease, diabetes, and high blood pressure—you're at a higher risk of heart failure and, eventually, end-stage heart failure. Other risk factors include poor diet, drug use, insufficient exercise, tobacco use, and obesity.

Preventing end-stage heart failure

Prevention is the best approach to heart failure. Adopting heart-healthy lifestyle habits can help you prevent or reduce the likelihood of conditions that lead to heart failure. Good habits include:

  • Diet: Eat lots of fresh fruits and vegetables, focus on lean proteins, and avoid salt, fat, sugar, and alcohol.
  • Drugs: Avoid tobacco and illegal drugs.
  • Manage conditions: Keep other conditions that affect your heart—like diabetes, high blood pressure, and high cholesterol—under control.
  • Rest: Prioritize getting enough good-quality sleep each night.
  • Fluids: Avoid excess fluid intake and follow your doctor’s instructions.

Diagnosing and treating end-stage heart failure

You may not receive a heart failure diagnosis until the later stages since the early stages of heart failure don't present symptoms. In other cases, if you have risk factors for heart failure, your doctor may monitor your heart for risk factors to try and identify heart failure early.

If you have heart failure, you'll get regular checks with your doctor, and they'll be able to tell you when your heart failure has progressed.

How is end-stage heart failure diagnosed?

Heart failure at all stages is diagnosed using the same tests and techniques:

  • Physical exam: Your doctor will ask about your symptoms and medical history. They'll also listen to your heart, check your blood pressure, and take your pulse. These initial indicators of your heart's performance help the doctor decide what tests to perform.
  • Lab tests: Blood and urine tests can detect conditions that can lead to heart failure, such as diabetes or anemia. A blood test for a compound called BNP can detect heart failure directly.
  • Heart activity tests: Your doctor may perform an electrocardiogram (abbreviated ECG or EKG) or exercise stress tests to assess your heart's performance at rest and during physical activity.
  • Cardiac imaging: Imaging technology like MRIs, CT scans, and echocardiograms can show abnormalities and diseases affecting the heart that may lead to heart failure. Echocardiograms can also show blood flow through the heart and indicate when the heart isn't pumping efficiently.

Advanced heart failure treatment

Fortunately, there are many ways to help manage end-stage heart failure. Treatment for the last stages of heart failure focuses on relieving symptoms, improving quality of life, and in rare cases, achieving recovery.

  • Support: Emotional and psychological support are critical parts of care for advanced heart failure. Psychological counseling, support groups, and care from loved ones all help a person with end-stage heart failure deal with the understandable fear, depression, and emotional distress that are normal parts of advanced heart failure.
  • Therapies: There are two lifesaving treatments available for patients with advanced heart failure.
    • Left ventricular assist devices (LVADs): These are artificial heart pumps surgically implanted help the heart pump blood. LVADs can significantly increase lifespan and improve the quality of life.
    • Heart transplantation: In highly selected cases, a heart transplant can replace the damaged heart with a healthy donor heart.
  • Palliative care: For patients unable to receive an LVAD or heart transplant, medications can help patients with end-stage heart failure manage their symptoms and live longer and more comfortably. Medications include ACE inhibitors, ARBs, beta-blockers, blood pressure medications, and diuretics. Patients may also undergo surgery to receive implantable devices like pacemakers and defibrillators that help their hearts work better.
  • Hospice: Hospice care focuses on giving you psychological support and the best quality of life in the time remaining. The choice to pursue hospice care is a personal one.

Stage D heart failure life expectancy

A diagnosis of end-stage heart failure can be overwhelming. It's normal to feel angry, depressed, anxious, and fearful. When you receive a diagnosis of end-stage heart failure, it is important to remember that several treatments are available, even in the later stages of the illness.

Life expectancy can vary depending on factors like age, medical history, and treatment options. On average, life expectancy is about two years after diagnosis of heart failure. In Stage D heart failure, life expectancy is typically less than a year. However, for patients who receive LVADs or a heart transplant, life expectancy can be extended well beyond 5-10 years, offering hope and the potential for a longer, fulfilling life.

FAQs about end-stage heart failure

While congestive heart failure is a serious condition, there are ways to manage end-stage heart failure, including two life-saving treatments:

  • Left ventricular assist devices (LVADs): These are artificial heart pumps surgically implanted help the heart pump blood. LVADs can significantly increase lifespan and improve the quality of life.
  • Heart transplantation: In highly selected cases, a heart transplant can replace the damaged heart with a healthy donor heart.

 

End-stage heart failure continues throughout the patient's life, but with the right treatments, there is hope for improving their condition and enhancing their quality of life.

Treatment can slow the progression of end-stage heart failure. Reversing the condition is only possible in some cases.

Typical signs of advanced heart failure include difficulty breathing, fatigue, swelling in the legs and abdomen, irregular heartbeat, and fatigue.

Hospice care focuses on giving the patient a comfortable and dignified end of life. In hospice, you won't get treatments to extend your life, but the care staff will help you manage symptoms and deal with the psychological distress and depression that accompany a diagnosis.