As we approach the new year, we connected with cardiovascular research experts across Mass General Brigham to see what scientific breakthroughs or advancements they predict will happen in 2025.
"I believe in 2025 we can expect to see the completion of the first large outcomes-focused clinical trial from a group of new medications that target lipoprotein(a), a unique type of 'bad cholesterol' that increases a patient’s risk for cardiovascular disease. Up to this point, the treatment paradigm for patients with elevated lipoprotein(a) has been to aggressively modify other risk factors, but we may soon have more targeted treatment options."
"Cardiac critical care has transformed into its own discipline but remains largely reactive to treating patients as they become sicker. I envision in 2025, the discovery of molecular biomarkers will shift the care paradigm to a more proactive approach. Molecular biomarkers may help us identify patients most at risk of disease and start interventions earlier, maybe even preventively."
Edy Kim, MD, PhD
Investigator, Pulmonary Division
Brigham and Women’s Hospital
"I predict that in 2025 we will see significant advancements in women's health research. In particular, I hope to see major breakthroughs that improve quality of life and cardiovascular health in mid-life/menopausal women, a group that has been historically underappreciated."
Emily S. Lau, MD, MPH
Investigator, Cardiometabolic Health and Hormones Clinic
Massachusetts General Hospital
"In 2025, I anticipate we will see the introduction of two intertwined advances. First, the integration of artificial intelligence (AI) facilitated algorithms for the early detection of cardiovascular illness, which will move us closer towards early prevention. We also envision a focus on using genetically informed treatments to reduce the risk of atherosclerotic heart disease, valvular heart disease and heart failure. Together, these important advances will usher in an era of personalized healthcare in cardiovascular disease."
Mandeep R. Mehra, MBBS, MSc
Executive Director, Center for Advanced Heart Disease
Brigham and Women’s Hospital
"In the coming year, I anticipate a marked increase in focus on cardio-kidney-metabolic health necessitating new patient-centered models of interdisciplinary care."
